ArchivIA - Archivio istituzionale dell'Universita' di Catania >
Tesi >
Tesi di dottorato >
Area 06 - Scienze mediche >
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10761/3800
|
Data: | 12-dic-2017 |
Autori: | Cavalli, Eugenio |
Titolo: | Role for Macrophage Migration Inhibitory Factor in Multiple Sclerosis |
Abstract: | Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of numerous inflammatory and autoimmune disorders. As such, it is an attractive therapeutic target for the treatment of these disorders. . Several data suggest a key role of MIF in the pathogenesis of Multiple Sclerosis (MS). In mice with EAE, an animal model of MS, MIF was found to be upregulated in the affected tissue . Immunoneutralization or genetic depletion of MIF reduced the severity of the disease by impairing the migration of autoreactive T cells to the CNS and downregulating the inflammatory cytokine production and the inhibition of MIF actions by usage of neutralizing anti-MIF antibodies has also proven therapeutically effective. However, more potent and specific inhibitors targeting MIF or its downstream effects are needed for the development of novel pharmaceutical therapies for MIF- associated diseases, such as MS. |
In | Area 06 - Scienze mediche
|
Full text:
File |
Descrizione |
Dimensioni | Formato | Consultabilità |
CVLGNE83H28F205N-Tesi dottorato Eugenio pdfA.pdf | Tesi Dottorato Eugenio Cavalli | 1,32 MB | Adobe PDF | Visualizza/apri
|
|
Tutti i documenti archiviati in ArchivIA sono protetti da copyright. Tutti i diritti riservati.
|