ArchivIA Università degli Studi di Catania
 

ArchivIA - Archivio istituzionale dell'Universita' di Catania >
Tesi >
Tesi di dottorato >
Area 06 - Scienze mediche >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10761/4032

Issue Date: 23-Feb-2017
Authors: Rubino, Alfonso
Title: Parkinson Disease subtype: morphostructural and neurobiological correlates
Abstract: The current view of malady reconsider PD as a complex clinicopathological entity, where the proteiform multiorgan involvement results from convergent multifactorial biomolecular substrates. It follows that, from a clinical point of view, PD presents as an extremely heterogeneous disorder with a wide range of symptoms and scarcely predictable progression trajectories. Therefore, it become necessary subtyping PD in order to better define the pathogenic process, the clinical progression and the response to treatment. However, the precise mechanistic insights are hindered by the lack of understanding of how risk variants and environment functionally connect to the pathogenesis and progression of PD. In this term, the subtypes in Parkinson disease could not be easily ascribable to discrete clinical entities, but rather the resultant of a multifactorial continuum influenced by several genetic, epigenetic, age-related and environmental factors.
Appears in Collections:Area 06 - Scienze mediche

Files in This Item:

File Description SizeFormatVisibility
RBNLNS80A02G795S-T AR XXVIII.pdfThesis AR XXVIII2,2 MBAdobe PDFView/Open


Items in ArchivIA are protected by copyright, with all rights reserved, unless otherwise indicated.


Share this record
Del.icio.us

Citeulike

Connotea

Facebook

Stumble it!

reddit


 

  Browser supportati Firefox 3+, Internet Explorer 7+, Google Chrome, Safari

ICT Support, development & maintenance are provided by the AePIC team @ CILEA. Powered on DSpace Software.