ArchivIA Università degli Studi di Catania
 

ArchivIA - Archivio istituzionale dell'Universita' di Catania >
Tesi >
Tesi di dottorato >
Area 06 - Scienze mediche >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10761/4128

Issue Date: 6-Sep-2019
Authors: Maugeri, Andrea Giuseppe
Title: DNA methylation landscape in retinal degenerative diseases: implications for Public Health at the crossroad between genes and diet
Abstract: The present study reveals the role of DNA methylation process in the pathophysiology of retinal degenerative diseases, exploiting a multiple integrated approach. Findings from in vitro studies uncovered how pathological features of retinal degeneration - including oxidative stress, inflammation and hyperglycaemia - modulate DNMTs and SIRT1 functions, affecting LINE-1 methylation levels in retinal cells. However, what we have seen in retinal cells differed from that observed in peripheral blood of AMD patients. Thus, further research - which takes into account genetic susceptibility - is needed to understand the mechanistic underpinnings of retinal degeneration. In addition, we proved that resveratrol and curcumin may restore DNA methylation changes which occur in cells under oxidative, inflammatory or high glucose conditions. The use of these compounds - together with the promotion of healthy diet - represent promising preventive and therapeutic approaches to tackle the increased burden of retinal degenerative diseases.
Appears in Collections:Area 06 - Scienze mediche

Files in This Item:

File Description SizeFormatVisibility
MGRNRG88T28C351F-PhD Thesis Andrea Maugeri.pdfPhD Thesis Andrea Maugeri4,65 MBAdobe PDFView/Open


Items in ArchivIA are protected by copyright, with all rights reserved, unless otherwise indicated.


Share this record
Del.icio.us

Citeulike

Connotea

Facebook

Stumble it!

reddit


 

  Browser supportati Firefox 3+, Internet Explorer 7+, Google Chrome, Safari

ICT Support, development & maintenance are provided by the AePIC team @ CILEA. Powered on DSpace Software.